As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment.
Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks / L. Riboni, L. Abdel Hadi, S. Navone, L. Guarnaccia, R. Campanella, G. Marfia. - In: CELLS. - ISSN 2073-4409. - 9:2(2020), pp. 337.1-337.37.
|Titolo:||Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks|
RIBONI, LAURA PIERA CARLA GIULIA (Primo) (Corresponding)
ABDEL HADI, LOUBNA (Secondo)
MARFIA, GIOVANNI (Ultimo)
|Parole Chiave:||sphingosine-1-phosphate; cancer; tumor microenvironment; glioblastoma; lysophospholipids; cancer hallmarks|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cells9020337|
|Appare nelle tipologie:||01 - Articolo su periodico|