Chronic kidney disease (CKD) patients have a higher risk of cardiovascular (CVD) morbidity and mortality compared to the general population. The links between CKD and CVD are not fully elucidated but encompass both traditional and uremic-related risk factors. The term CKD-mineral and bone disorder (CKD-MBD) indicates a systemic disorder characterized by abnormal levels of calcium, phosphate, PTH and FGF-23, along with vitamin D deficiency, decreased bone mineral density or altered bone turnover and vascular calcification. A growing body of evidence shows that CKD patients can be affected by subclinical vitamin K deficiency; this has led to identifying such a condition as a potential therapeutic target given the specific role of Vitamin K in metabolism of several proteins involved in bone and vascular health. In other words, we can hypothesize that vitamin K deficiency is the common pathogenetic link between impaired bone mineralization and vascular calcification. However, some of the most common approaches to CKD, such as (1) low vitamin K intake due to nutritional restrictions, (2) warfarin treatment, (3) VDRA and calcimimetics, and (4) phosphate binders, may instead have the opposite effects on vitamin K metabolism and storage in CKD patients.
Current Therapy in CKD Patients Can Affect Vitamin K Status / M. Cozzolino, G. Cianciolo, M.A. Podestà, P. Ciceri, A. Galassi, L. Gasperoni, G.L. Manna. - In: NUTRIENTS. - ISSN 2072-6643. - 12:6(2020 May 30).
|Titolo:||Current Therapy in CKD Patients Can Affect Vitamin K Status|
COZZOLINO, MARIO GENNARO (Primo)
|Parole Chiave:||vitamin K; chronic kidney disease; vascular calcification; secondary hyperparathyroidism; warfarin;|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||30-mag-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu12061609|
|Appare nelle tipologie:||01 - Articolo su periodico|