CDH1 germline mutation is the most important genetic mechanism that associates with the development of the hereditary diffuse gastric cancer syndrome. However, gastric carcinoma participates also in other inherited predispositions as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz Jeghers syndromes. While in these cases the gastric cancer risk is undefined and causative germline mutations are rarely identified, members of the family can be similarly tested and identified, providing targeted surveillance and management opportunities.
Gastric Cancer in Other Inherited Syndromes / G. Corso, S. Velho - In: Spotlight on Familial and Hereditary Gastric Cancer / [a cura di] G. Corso, F. Roviello. - [s.l] : Springer, 2013. - ISBN 9789400765696. - pp. 177-181 [10.1007/978-94-007-6570-2_15]
Gastric Cancer in Other Inherited Syndromes
G. Corso
;
2013
Abstract
CDH1 germline mutation is the most important genetic mechanism that associates with the development of the hereditary diffuse gastric cancer syndrome. However, gastric carcinoma participates also in other inherited predispositions as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz Jeghers syndromes. While in these cases the gastric cancer risk is undefined and causative germline mutations are rarely identified, members of the family can be similarly tested and identified, providing targeted surveillance and management opportunities.
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