E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
E-cadherin deregulation in breast cancer / G. Corso, J. Figueiredo, S.P. De Angelis, F. Corso, A. Girardi, J. Pereira, R. Seruca, B. Bonanni, P. Carneiro, G. Pravettoni, E. Guerini Rocco, P. Veronesi, G. Montagna, V. Sacchini, S. Gandini. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - (2020). [Epub ahead of print] [10.1111/jcmm.15140]
E-cadherin deregulation in breast cancer
G. Corso
Primo
;G. Pravettoni;E. Guerini Rocco;P. Veronesi;V. SacchiniPenultimo
;
2020
Abstract
E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
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