E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.

E-cadherin deregulation in breast cancer / G. Corso, J. Figueiredo, S.P. De Angelis, F. Corso, A. Girardi, J. Pereira, R. Seruca, B. Bonanni, P. Carneiro, G. Pravettoni, E. Guerini Rocco, P. Veronesi, G. Montagna, V. Sacchini, S. Gandini. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - (2020). [Epub ahead of print] [10.1111/jcmm.15140]

E-cadherin deregulation in breast cancer

G. Corso
Primo
;
G. Pravettoni;E. Guerini Rocco;P. Veronesi;V. Sacchini
Penultimo
;
2020

Abstract

E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
breast cancer; breast cancer metastases; breast cancer prognosis; breast cancer survival; E-cadherin
Settore MED/18 - Chirurgia Generale
2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
JCMM 15140 final.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 713 kB
Formato Adobe PDF
713 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/737678
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 67
  • ???jsp.display-item.citation.isi??? 50
social impact