The coupling and latency between heart period (HP) and systolic arterial pressure (SAP) variability can be investigated along the two arms of the HP-SAP closed loop, namely along the baroreflex feedback from SAP to HP, and along the feedforward pathway from HP to SAP. This study investigates the HP-SAP closed loop variability interactions through cross-correlation function (CCF). Coupling strength and delay between HP and SAP variability series were monitored in 13 subjects prone to develop orthostatic syncope (SYNC, 28±9 yrs, 5 males) and in 13 subjects with no history of postural syncope (noSYNC, age: 27±8 yrs, 5 males). Analysis was carried out at rest in supine position (REST) and during head-up tilt (TILT) at 60 degrees. The null hypothesis of HP-SAP uncoupling was tested through a surrogate analysis associating the HP series of a subject with a SAP sequence of a different one. Results showed that during TILT the coupling strength increased along the baroreflex and latency augmented along the mechanical feedforward pathway exclusively in noSYNC subjects. Finally, closed loop HP-SAP interactions were detected in about one third of subjects and the situation of full uncoupling was rarely found. CCF analysis was found to be a straightforward and easily applicable method to investigate HP-SAP control deserving a direct comparison with more sophisticated signal processing tools assessing causality.
Strength and latency of the HP-SAP closed loop variability interactions in subjects prone to develop postural syncope / V. Bari, B. Cairo, E. Vaini, B. De Maria, D. Tonon, G. Rossato, L. Faes, A. Porta (IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS). - In: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)[s.l] : IEEE Press, 2019. - ISBN 9781538613115. - pp. 2003-2006 (( Intervento presentato al 41. convegno Annual International Conference of the IEEE EMBS tenutosi a Berlin nel 2019 [10.1109/EMBC.2019.8856288].
Strength and latency of the HP-SAP closed loop variability interactions in subjects prone to develop postural syncope
V. Bari;B. Cairo;A. PortaUltimo
2019
Abstract
The coupling and latency between heart period (HP) and systolic arterial pressure (SAP) variability can be investigated along the two arms of the HP-SAP closed loop, namely along the baroreflex feedback from SAP to HP, and along the feedforward pathway from HP to SAP. This study investigates the HP-SAP closed loop variability interactions through cross-correlation function (CCF). Coupling strength and delay between HP and SAP variability series were monitored in 13 subjects prone to develop orthostatic syncope (SYNC, 28±9 yrs, 5 males) and in 13 subjects with no history of postural syncope (noSYNC, age: 27±8 yrs, 5 males). Analysis was carried out at rest in supine position (REST) and during head-up tilt (TILT) at 60 degrees. The null hypothesis of HP-SAP uncoupling was tested through a surrogate analysis associating the HP series of a subject with a SAP sequence of a different one. Results showed that during TILT the coupling strength increased along the baroreflex and latency augmented along the mechanical feedforward pathway exclusively in noSYNC subjects. Finally, closed loop HP-SAP interactions were detected in about one third of subjects and the situation of full uncoupling was rarely found. CCF analysis was found to be a straightforward and easily applicable method to investigate HP-SAP control deserving a direct comparison with more sophisticated signal processing tools assessing causality.File | Dimensione | Formato | |
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