Cerebral autoregulation (CA) maintainsmean cerebral blood flow velocity (MCBFV) stable in spite ofvariations in mean arterial pressure (MAP). Propofol anesthesia is known to preserveCA, although informationon the anesthesia effect on MCBFV and MAP variability coupling at sedation levelstypical of major cardiac surgeryislimited. MAP and MCBFVtime serieswere respectively recordedfrom radial artery and left middle cerebral artery via transcranial Doppler,before (PRE) and after (POST) general anesthesia induction with propofol and remifentanil in 10 male subjects (age 64.7±7.0 years) undergoing coronary artery bypass grafting.Squared coherence(K2)wascomputed inthe typical bandsof CA, namely very low (0.02-0.07 Hz), low (0.07-0.15 Hz) and high frequency (0.15-0.4 Hz). The null hypothesis of coupling was tested through a surrogate analysis associatingMAP and MCBFV series taken from different patientsin the same experimental condition. MAP and MCBFV original series were significantly more associated than surrogate ones during PRE. K2was reduced in the three frequency bandsduring POSTto a level comparable with surrogates. By decoupling MCBFVandMAP propofol general anesthesiafavorssituations of stable MCBFV in response to slow modifications of MAPbut the full decoupling might hide the limited resources of the cerebrovascular control toactively regulateMCBFV.

Propofol general anesthesia decreases the coupling strength between mean arterial blood pressure and mean cerebral blood flow velocity in patients undergoing coronary artery bypass grafting / V. Bari, E. Vaini, A. Fantinato, B. De Maria, B. Cairo, V. Pistuddi, M. Ranucci, A. Porta. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-887X. - 46:(2019). (Intervento presentato al convegno Computing in Cardiology: 8th - 11th September tenutosi a Singapore nel 2019) [10.23919/CinC49843.2019.9005930].

Propofol general anesthesia decreases the coupling strength between mean arterial blood pressure and mean cerebral blood flow velocity in patients undergoing coronary artery bypass grafting

V. Bari
Primo
;
B. Cairo;A. Porta
Ultimo
2019

Abstract

Cerebral autoregulation (CA) maintainsmean cerebral blood flow velocity (MCBFV) stable in spite ofvariations in mean arterial pressure (MAP). Propofol anesthesia is known to preserveCA, although informationon the anesthesia effect on MCBFV and MAP variability coupling at sedation levelstypical of major cardiac surgeryislimited. MAP and MCBFVtime serieswere respectively recordedfrom radial artery and left middle cerebral artery via transcranial Doppler,before (PRE) and after (POST) general anesthesia induction with propofol and remifentanil in 10 male subjects (age 64.7±7.0 years) undergoing coronary artery bypass grafting.Squared coherence(K2)wascomputed inthe typical bandsof CA, namely very low (0.02-0.07 Hz), low (0.07-0.15 Hz) and high frequency (0.15-0.4 Hz). The null hypothesis of coupling was tested through a surrogate analysis associatingMAP and MCBFV series taken from different patientsin the same experimental condition. MAP and MCBFV original series were significantly more associated than surrogate ones during PRE. K2was reduced in the three frequency bandsduring POSTto a level comparable with surrogates. By decoupling MCBFVandMAP propofol general anesthesiafavorssituations of stable MCBFV in response to slow modifications of MAPbut the full decoupling might hide the limited resources of the cerebrovascular control toactively regulateMCBFV.
Settore ING-INF/06 - Bioingegneria Elettronica e Informatica
2019
Article (author)
File in questo prodotto:
File Dimensione Formato  
VBari_CinC_2019.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 1.74 MB
Formato Adobe PDF
1.74 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/735884
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact