IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

D-Dimer Elevation in Spontaneous Urticaria and Bullous Pemphigoid, Two Chronic Inflammatory Skin Diseases

Calibrating Reliance: Addressing Misuse and Disuse in AI-Based Second-Opinion Systems for Medical Diagnosis

AI systems are widely proposed as second-opinion advisors in clinical diagnosis, offering the promise of enhancing decision accuracy and clinician confidence while preserving human oversight. However, successful deployment in real-world practice faces a critical barrier: clinicians' reliance on AI is often miscalibrated, manifesting as misuse (over-reliance driven by automation bias) and disuse (under-utilization driven by self-anchoring bias). This paper addresses these deployment challenges...

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain-like behaviors in rats with neuropathic pain

Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) channels regulate action potential firing in nociceptors and are critical mediators of neuronal hyperexcitability in response to inflammation and nerve injury. These channels are activated by membrane hyperpolarization and potentiated by direct cAMP binding to their C-terminal cyclic nucleotide-binding domain (CNBD). Although a role for cAMP in modulating HCN2 activity and contributing to neuropathic pain has been hypothesized, dire...

From flexible leaders to innovative followers: A multilevel study of leader cognitive flexibility, psychological empowerment, leader identification and innovative behavior

This study examines the role of leader cognitive flexibility in fostering followers' innovative work behavior (IWB). Drawing on social learning theory, we propose that cognitively flexible leaders create an environment that inspires followers to generate, promote, and implement innovative ideas. Additionally, we investigate the mediating role of psychological empowerment and the moderating role of leader identification in shaping this relationship. We conducted a three-wave, multilevel study ...