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High-Fidelity simulation and its impact on non-technical skills development among healthcare professionals: A systematic review and meta-analysis

Background and aim: High-Fidelity Simulation (HFS) has emerged as a pivotal educational strategy in healthcare, particularly for bridging the gap between theoretical knowledge and practical application. This systematic review and meta-analysis aimed to investigate the efficacy of HFS in enhancing non-technical skills among healthcare professionals. Methods: The literature search was conducted in PubMed, Embase, Scopus, CINAHL, and Google Scholar covering the period from February 2012 to Augus...

Rapamycin reverts TDP-43 splicing defects and mislocalization in human in vitro models of TDP-43 proteinopathy

Aggregates of phosphorylated and ubiquitinated TDP-43 protein in the cytoplasm of neurons are an ALS neuropathological hallmark. Response to stress and formation of stress granules (SG) have been proposed as initiators of TDP-43 pathological aggregation. We previously showed that mild and chronic oxidative stress by arsenite (ARS) induces formation of both SG and phospho-TDP-43 aggregates in primary fibroblasts and iPSC-motor neurons obtained from ALS patients in association to the accumulati...

Confronto Europa-USA: la parola agli esperti

In questa intervista doppia con Jen-Yun Chou e Thomas Parsons approfondiamo quali sono e da dove scaturiscono le differenze sul modo in cui vengono allevati i suini in Europa e negli Stati Uniti.

No Headache for PIPs: A PIP Potential for Aspirin Runs Much Faster and with Similar Precision Than Other Machine-Learned Potentials

Assessments of machine-learning (ML) potentials are an important aspect of the rapid development of this field. We recently reported an assessment of the linear-regression permutationally invariant polynomial (PIP) method for ethanol, using the widely used (revised) rMD17 data set. We demonstrated that the PIP approach outperformed numerous other methods, e.g., ANI, PhysNet, sGDML, and p-KRR, with respect to precision and notably with respect to speed [Houston et al., J. Chem. Phys. 2022, 156...

The role of Voltage-Gated Sodium Channels in neuronal differentiation and their contribution to Amyotrophic Lateral Sclerosis pathogenesis

Voltage-gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit and one or two accessory beta subunits. These channels are responsible for the generation of inward Na+ currents. A small fraction of these currents is represented by a non-inactivating component, the persistent Na+ current or INaP. Recent evidence suggests that VGSCs and INaP are important not only in the regulation of excitable cell electrical properties but also in promoting neuronal developm...

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  • Article (author)188930
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  • Working Paper1572
  • Book (translator)488
  • Patent455
  • Journal volume (editor)433
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  • Multimedia Object (author)380
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  • Exhibition74
  • Multimedia Object (editor)38
  • Map30
  • Tesi di specializzazione12
  • Exhibition Part6
  • Protocol (author)6
  • Protocol (editor)1
Autore
  • LA VECCHIA, CARLO VITANTONIO BATT...2514
  • RAGUSA, FRANCESCO1407
  • GATTINONI, LUCIANO1394
  • ANDREAZZA, ATTILIO1168
  • NERI, NICOLA1164
  • PERINI, LAURA1098
  • CARMINATI, LEONARDO CARLO1059
  • FANTI, MARCELLO1058
  • D'AURIA, SAVERIO1047
  • NEGRI, EVA VANNA LORENZA1034
Data di pubblicazione
  • 2020 - 202447880
  • 2010 - 2019125122
  • 2000 - 200986334
  • 1990 - 199920188
  • 1980 - 19897209
  • 1970 - 19791141
  • 1960 - 196964
  • 1959 - 19591
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  • Università degli Studi di Milano6296
  • MDPI5167
  • Wiley4815
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  • Settore MED/09 - Medicina Interna8708
  • Settore INF/01 - Informatica7786
  • Settore BIO/10 - Biochimica6181
  • Settore MED/26 - Neurologia5620
  • Settore MED/18 - Chirurgia Generale5550
  • Settore MED/28 - Malattie Odontos...5269
  • Settore MED/04 - Patologia Generale5203
  • Settore CHIM/06 - Chimica Organica5058
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  • Female3504
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  • Middle Aged2136
  • Adult2068
  • Italy1867
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  • ESCUDO CLOUD50
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  • 1H_Hub46
  • ENSAR244
  • ABC4EU40
  • MUSA38
  • SERICS38