IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

A Randomized Phase II Study of Sunitinib vs. Standard of Care for Patients with Previously Treated Advanced Triple-Negative Breast Cancer

Tumor infiltrating lymphocytes across breast cancer subtypes: current issues for biomarker assessment

Tumor-infiltrating lymphocytes (TILs) represent a surrogate biomarker of anti-tumor, lymphocyte-mediated immunity. In early, triple-negative breast cancer, TILs have level 1B of evidence to predict clinical outcomes. TILs represent a promising biomarker to select patients who can experience a better prognosis with de-intensified cancer treatments and derive larger benefits from immune checkpoint inhibitors. However, the assessment and the validation of TILs as a biomarker require a prospectiv...

Dal taglio dei parlamentari alla riforma del premierato. Il Senato delle Regioni quale argine alla verticalizzazione decisionale per rivitalizzare la democrazia rappresentativa

This paper examines the ongoing process of constitutional reform in Italy, focusing on the proposed introduction of a directly elected Prime Minister. This reform represents the culmination of a long-standing trend towards the verticalization of power, a process that has been exacerbated by the crisis of political parties and the increasing centralization of decision making authority in the hands of the executive. The study highlights the risks associated with this shift, including the erosio...

AI-Enabled First-Response Support After Sexual and Gender-Based Violence: A PRISMA-ScR Scoping Review

Background: Artificial intelligence (AI) is increasingly proposed to augment early-stage assistance for survivors of sexual and gender-based violence (GBV), including intimate partner and domestic violence, across crisis hotlines, specialist services, digital reporting channels, legal support tools and healthcare pathways. However, the scope, maturity and evaluative strength of the peer-reviewed evidence remain uncertain. We aimed to map the application domains, evaluative maturity, and imple...