Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.

Gabapentin affects the expression of inflammatory mediators on healthy gingival cells / V. Candotto, L. Scapoli, R.M. Gaudio, A.B. Gianni, A. Bolzoni, P. Racco, D. Lauritano, F. Cura. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 33(2019 Oct). [10.1177/2058738419827765]

Gabapentin affects the expression of inflammatory mediators on healthy gingival cells

V. Candotto;A.B. Gianni;A. Bolzoni;
2019

Abstract

Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.
fibroblasts; gabapentin; gingival overgrowth; inflammation; Adult; Aged; Cells, Cultured; Chemokines; Cytokines; Female; Fibroblasts; Gabapentin; Gingiva; Healthy Volunteers; Humans; Inflammation; Inflammation Mediators; Interleukins; Male; Young Adult
Settore MED/29 - Chirurgia Maxillofacciale
ott-2019
Article (author)
File in questo prodotto:
File Dimensione Formato  
Gabapentin affects the expression.... GIANNI' Bolzoni Candotto.pdf

accesso aperto

Descrizione: articolo principale
Tipologia: Publisher's version/PDF
Dimensione 576.98 kB
Formato Adobe PDF
576.98 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/734150
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 11
social impact