This prospective case-control study was conducted to examine whether spherical deconvolution (SD) can unveil microstructural abnormalities in the corticospinal tract (CST) caused by IDH-mutant gliomas. To determine the significance of abnormal microstructure, the authors investigated the correlation between diffusion parameters and neurophysiological data collected with navigated transcranial magnetic stimulation (nTMS).

Altered corticospinal microstructure and motor cortex excitability in gliomas : an advanced tractography and transcranial magnetic stimulation study / A.S. Mirchandani, A. Beyh, J.P. Lavrador, H. Howells, F. Dell'Acqua, F. Vergani. - In: JOURNAL OF NEUROSURGERY. - ISSN 0022-3085. - 134:5(2021 May), pp. 1368-1376. [10.3171/2020.2.JNS192994]

Altered corticospinal microstructure and motor cortex excitability in gliomas : an advanced tractography and transcranial magnetic stimulation study

H. Howells;
2021

Abstract

This prospective case-control study was conducted to examine whether spherical deconvolution (SD) can unveil microstructural abnormalities in the corticospinal tract (CST) caused by IDH-mutant gliomas. To determine the significance of abnormal microstructure, the authors investigated the correlation between diffusion parameters and neurophysiological data collected with navigated transcranial magnetic stimulation (nTMS).
AD = axial diffusivity; CST = corticospinal tract; DTI = diffusion tensor imaging; FA = fractional anisotropy; HMOA = hindrance modulated orientational anisotropy; MD = mean diffusivity; MEP = motor evoked potential; MRC = Medical Research Council; RD = radial diffusivity; ROI = region of interest; SD = spherical deconvolution; corticospinal tract; fODF = fiber orientation distribution function; low-grade gliomas; nTMS = navigated transcranial magnetic stimulation; oncology; pathological excitability; rMT = resting motor threshold; resting motor threshold; spherical deconvolution; tractography; transcranial magnetic stimulation
Settore BIO/16 - Anatomia Umana
mag-2021
1-mag-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/733690
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