Various kinds of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allows for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected “systemic” response to treatments designed to be “local”. In the present article the mechanisms of action of HIFU are described, and the main clinical applications of this technique are reported, with a particular focus on the immune-stimulation process that might originate from tumour ablations.

Focused ultrasound : tumour ablation and its potential to enhance immunological therapy to cancer / G. Mauri, L. Nicosia, Z. Xu, S. Di Pietro, L. Monfardini, G. Bonomo, G.M. Varano, F. Prada, P. Della Vigna, F. Orsi. - In: BRITISH JOURNAL OF RADIOLOGY. - ISSN 0007-1285. - 91:1083(2018 Feb), pp. 20170641.1-20170641.9.

Focused ultrasound : tumour ablation and its potential to enhance immunological therapy to cancer

G. Mauri;L. Nicosia
;
S. Di Pietro;P. Della Vigna;
2018

Abstract

Various kinds of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allows for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected “systemic” response to treatments designed to be “local”. In the present article the mechanisms of action of HIFU are described, and the main clinical applications of this technique are reported, with a particular focus on the immune-stimulation process that might originate from tumour ablations.
Settore MED/36 - Diagnostica per Immagini e Radioterapia
feb-2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
bjr.20170641.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 455.07 kB
Formato Adobe PDF
455.07 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/733233
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 63
social impact