Central to the pathophysiology of sepsis and septic shock is an alteration in endothelial cell function and oxidative stress. Highly complex, integrated responses that include the activation of a number of cell types, inflammatory mediators and the hemostatic system are involved in endothelial dysfunction. On the other hand, the imbalance between the excessive production of reactive oxygen species and/or inadequate antioxidative defenses characterizes the oxidative stress. The overview of all these mechanisms suggests clinical biochemical markers as a possible therapeutic target together with correct intervention timing.
Disfunzione endoteliale e stress ossidativo nella sepsi / O. Parodi, B. De Chiara, J. Campolo, V. Sedda, E. Roubina. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 0393-5590. - 23:S36(2006), pp. S69-S73.
Disfunzione endoteliale e stress ossidativo nella sepsi
B. De ChiaraSecondo
;V. SeddaPenultimo
;
2006
Abstract
Central to the pathophysiology of sepsis and septic shock is an alteration in endothelial cell function and oxidative stress. Highly complex, integrated responses that include the activation of a number of cell types, inflammatory mediators and the hemostatic system are involved in endothelial dysfunction. On the other hand, the imbalance between the excessive production of reactive oxygen species and/or inadequate antioxidative defenses characterizes the oxidative stress. The overview of all these mechanisms suggests clinical biochemical markers as a possible therapeutic target together with correct intervention timing.Pubblicazioni consigliate
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