COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. Design: This Italian prospective observational cohort study enrolled consecutive patients with an established IBD diagnosis and confirmed COVID-19. Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death). Results: Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled at 24 IBD referral units. Thirty-six patients had COVID-19-related pneumonia (46%), 22 (28%) were hospitalised, 7 (9%) required non-mechanical ventilation, 9 (11%) required continuous positive airway pressure therapy, 2 (3%) had endotracheal intubation and 6 (8%) died. Four patients (6%) were diagnosed with COVID-19 while they were being hospitalised for a severe flare of IBD. Age over 65 years (p=0.03), UC diagnosis (p=0.03), IBD activity (p=0.003) and a CCI score >1 (p=0.04) were significantly associated with COVID-19 pneumonia, whereas concomitant IBD treatments were not. Age over 65 years (p=0.002), active IBD (p=0.02) and higher CCI score were significantly associated with COVID-19-related death. Conclusions: Active IBD, old age and comorbidities were associated with a negative COVID-19 outcome, whereas IBD treatments were not. Preventing acute IBD flares may avoid fatal COVID-19 in patients with IBD. Further research is needed.
Outcomes of COVID-19 in 79 patients with IBD in Italy : an IG-IBD study / C. Bezzio, S. Saibeni, A. Variola, M. Allocca, A. Massari, V. Gerardi, V. Casini, C. Ricci, F. Zingone, A. Amato, F. Caprioli, M.V. Lenti, C. Viganò, M. Ascolani, F. Bossa, F. Castiglione, C. Cortelezzi, L. Grossi, M. Milla, D. Morganti, L. Pastorelli, D.G. Ribaldone, A. Sartini, A. Soriano, G. Manes, S. Danese, M. Fantini, A. Armuzzi, M. Daperno, G. Fiorino. - In: GUT. - ISSN 0017-5749. - (2020 Apr 30). [Epub ahead of print]
|Titolo:||Outcomes of COVID-19 in 79 patients with IBD in Italy : an IG-IBD study|
|Parole Chiave:||IBD; epidemiology|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||30-apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1136/gutjnl-2020-321411|
|Appare nelle tipologie:||01 - Articolo su periodico|