MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress / N. Volk, J.C. Pape, M. Engel, A.S. Zannas, N. Cattane, A. Cattaneo, E.B. Binder, A. Chen. - In: CELL REPORTS. - ISSN 2211-1247. - 17:7(2016), pp. 1882-1891.
|Titolo:||Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress|
|Parole Chiave:||social defeat stress; induced anxiety; adult mice; depression; fear; FKBP5; memory; gene; association; resilience|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.celrep.2016.10.038|
|Appare nelle tipologie:||01 - Articolo su periodico|