IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishNeuroactive steroids, molecules produced from cholesterol in steroidogenic cells (i.e., peripheral glands and nervous system) are physiological modulators and protective agents of nervous function. A possible role for neuroactive steroids in the sex-dimorphic clinical manifestation, onset and progression of Multiple Sclerosis (MS) has been recently suggested. To explore this possibility, we assessed the synthesis of the first steroidogenic product (pregnenolone; PREG) in the spinal cord of experimental autoimmune encephalomyelitis rats, a MS model. Data obtained indicate that the synthesis of PREG in the spinal cord is altered by the pathology in a sex-dimorphic way and depending on the pathological progression. Indeed, in male spinal cord the synthesis was already decreased at the acute phase of the disease (i.e., 14 days post induction - dpi) and maintained low during the chronic phase (i.e., 45 dpi), while in females this effect was observed only at the chronic phase. Substrate availability had also a role in the sex-dimorphic kinetics. Indeed, at the chronic phase, male animals showed a reduction in the levels of free cholesterol coupled to alteration of cholesterol metabolism into oxysterols; these effects were not observed in female animals. These findings suggest that the comprehension of the neurosteroidogenic processes could be relevant to better understand the sexual dimorphism of MS and to possibly design sex-oriented therapeutic strategies based on neuroactive steroids.
Sex dimorphism in an animal model of multiple sclerosis : Focus on pregnenolone synthesis / S. Giatti, R. Rigolio, S. Diviccaro, E. Falvo, D. Caruso, L.M. Garcia-Segura, G. Cavaletti, R.C. Melcangi. - In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. - ISSN 0960-0760. - 199(2020 May), pp. 105596.1-105596.7.
| Titolo: | Sex dimorphism in an animal model of multiple sclerosis : Focus on pregnenolone synthesis |
| Autori: | GIATTI, SILVIA (Primo) MELCANGI, COSIMO (Ultimo) (Corresponding) |
| Parole Chiave: | Cholesterol; Female; Male; Multiple sclerosis; Oxysterols; Pregnenolone; Spinal cord |
| Settore Scientifico Disciplinare: | Settore MED/13 - Endocrinologia Settore BIO/10 - Biochimica |
| Data di pubblicazione: | mag-2020 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jsbmb.2020.105596 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 1-s2.0-S0960076019306995-main.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
Copyright © 2020