Human neuroimaging studies indicate that the amygdala plays a key role in cocaine addiction. One key plasticity factor that modulates effects of cocaine on the brain is Brain-Derived Neurotrophic Factor (BDNF). A wealth of evidence shows that cocaine exposure alters BDNF signaling in corticolimbic structures, but, surprisingly, such evidence is very limited for the amygdala. Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naïve and cocaine exposure conditions are unknown.

Deletion of the serotonin transporter perturbs BDNF signaling in the central amygdala following long-access cocaine self-administration / L. Caffino, F. Mottarlini, D.M. Diniz, M.M. Verheij, F. Fumagalli, J.R. Homberg. - In: DRUG AND ALCOHOL DEPENDENCE. - ISSN 0376-8716. - 205(2019 Dec 01). [10.1016/j.drugalcdep.2019.107610]

Deletion of the serotonin transporter perturbs BDNF signaling in the central amygdala following long-access cocaine self-administration

L. Caffino
Primo
;
F. Mottarlini
Secondo
;
F. Fumagalli
Penultimo
;
2019

Abstract

Human neuroimaging studies indicate that the amygdala plays a key role in cocaine addiction. One key plasticity factor that modulates effects of cocaine on the brain is Brain-Derived Neurotrophic Factor (BDNF). A wealth of evidence shows that cocaine exposure alters BDNF signaling in corticolimbic structures, but, surprisingly, such evidence is very limited for the amygdala. Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naïve and cocaine exposure conditions are unknown.
Amygdala; BDNF; Cocaine self-administration; Serotonin
Settore BIO/14 - Farmacologia
1-dic-2019
6-ott-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/731222
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