Unexpected sudden cardiac death (SCD), sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD) are major unsolved, devastating forms of death that occur frequently. Obstructive sleep apnea (OSA) has been associated with increased cardiovascular and cerebrovascular morbidity and mortality, including sudden cardiac death (SCD). This editorial will review the pathology of SCD, including sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD); OSA with its cardiovascular consequences; the possible link between SCD and OSA, discussing the potential mechanisms underlying these two frequent, but yet overlooked pathologies. Finally, the possible preventive benefits of treating OSA and identifying patients at common risk for OSA and SCD and SIDS-SIUD to prevent unexpected deaths will be discussed. Post-mortem examination is of great importance in every case of SCD sine materia, with examination of the brainstem and cardiac conduction system on serial sections, when general autopsy fails, but it should be stressed that also the investigations of patients suffering from OSA should focus on the possibility of pathological findings in common with cases of SCD.
Pathology of unexpected sudden cardiac death : Obstructive sleep apnea is part of the challenge / G. Ottaviani, L.M. Buja. - In: CARDIOVASCULAR PATHOLOGY. - ISSN 1054-8807. - 47(2020 Aug).
|Titolo:||Pathology of unexpected sudden cardiac death : Obstructive sleep apnea is part of the challenge|
OTTAVIANI, GIULIA MARIA ELISA (Primo) [Conceptualization] (Corresponding)
|Parole Chiave:||obstructive sleep apnea; post-mortem examination; sudden infant death syndrome; sudden intrauterine unexplained death; unexpected sudden cardiac death;|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||ago-2020|
|Centro di ricerca:||Centro di Ricerca "Lino Rossi" per lo studio e la prevenzione della morte perinatale del feto a termine e neonatale e della sindrome della morte improvvisa del lattante SIDS|
|Data ahead of print / Data di stampa:||18-apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.carpath.2020.107221|
|Appare nelle tipologie:||01 - Articolo su periodico|