N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors. NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or GluN3-type, leading to the existence in the central nervous system of a high variety of receptor subtypes with different pharmacological and signaling properties. NMDAR subunit composition is strictly regulated during development and by activity-dependent synaptic plasticity. Given the differences between GluN2 regulatory subunits of NMDAR in several functions, here we will focus on the synaptic pool of NMDARs containing the GluN2A subunit, addressing its role in both physiology and pathological synaptic plasticity as well as the contribution in these events of different types of GluN2A-interacting proteins.
Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity / L. Franchini, N. Carrano, M. Di Luca, F. Gardoni. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:4(2020 Feb 24).
|Titolo:||Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity|
FRANCHINI, LUCA (Primo)
CARRANO, NICOLO' (Secondo)
DILUCA, MONICA MARIA GRAZIA (Penultimo)
GARDONI, FABRIZIO (Ultimo) (Corresponding)
|Parole Chiave:||Glutamate; NMDA receptors; brain disorders; dendritic spines; synaptic plasticity|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||24-feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21041538|
|Appare nelle tipologie:||01 - Articolo su periodico|