Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.

Formal alpha-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles / F. Franco, S. Meninno, M. Benaglia, A. Lattanzi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 56:20(2020), pp. 3073-3076.

Formal alpha-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

M. Benaglia;
2020

Abstract

Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.
hypervalent iodonium ylide; electrophilic trifluoromethylthiolation; catalyzed trifluoromethylthiolation; enantioselective synthesis; substituent constants; diazo esters; fluorine; reagents; reactivity; discovery
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/730526
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