Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.
Formal alpha-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles / F. Franco, S. Meninno, M. Benaglia, A. Lattanzi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 56:20(2020), pp. 3073-3076. [10.1039/d0cc00116c]
Formal alpha-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles
M. Benaglia;
2020
Abstract
Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.
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