When naive T cells home to lymph nodes, they first roll along high endothelial venules using CD62L, allowing the chemokine receptor CCR7 to engage its ligand, SLC, displayed by endothelial cells. The CCR7-SLC interaction activates integrins that promote firm adhesion and transmigration of the T cells into the lymph node (Butcher and Picker, 1996; Cyster, 1999).
Functional subsets of memory T cells identified by CCR7 expression / F. Sallusto, A. Langenkamp, J. Geginat, A. Lanzavecchia. - In: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. - ISSN 0070-217X. - 251(2000), pp. 167-171.
Functional subsets of memory T cells identified by CCR7 expression
J. Geginat;
2000
Abstract
When naive T cells home to lymph nodes, they first roll along high endothelial venules using CD62L, allowing the chemokine receptor CCR7 to engage its ligand, SLC, displayed by endothelial cells. The CCR7-SLC interaction activates integrins that promote firm adhesion and transmigration of the T cells into the lymph node (Butcher and Picker, 1996; Cyster, 1999).
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