The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T-CM) and effector memory (T-EM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of T-CM and T-EM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.

Central memory and effector memory T cell subsets: function, generation, and maintenance / F. Sallusto, J. Geginat, A. Lanzavecchia. - In: ANNUAL REVIEW OF IMMUNOLOGY. - ISSN 0732-0582. - 22(2004), pp. 745-763.

Central memory and effector memory T cell subsets: function, generation, and maintenance

J. Geginat;
2004

Abstract

The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T-CM) and effector memory (T-EM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of T-CM and T-EM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.
T(H)1/T(H)2; T lymphocyte activation; chemokine receptors; lymphocyte migration; effector function
Settore MED/04 - Patologia Generale
2004
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/730439
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