Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides TGF-beta and IL-35. It is produced by activated immune cells, in particular monocytes/macrophages and T cell subsets including Tr1, Treg, and Th1 cells. IL-10 acts through a transmembrane receptor complex, which is composed of IL-10R1 and IL-10R2, and regulates the functions of many different immune cells. In monocytes/macrophages, IL-10 diminishes the production of inflammatory mediators and inhibits antigen presentation, although it enhances their uptake of antigens. Additionally, IL-10 plays an important role in the biology of B cells and T cells. The special physiological relevance of this cytokine lies in the prevention and limitation of over-whelming specific and unspecific immune reactions and, in consequence, of tissue damage. At the same time, IL-10 strengthens the "scavenger"-function and contributes to induced tolerance. This review provides an overview about the cellular sources, molecular mechanisms, effects, and biological role of IL-10.
Biology of interleukin-10 / R. Sabat, G. Grütz, K. Warszawska, S. Kirsch, E. Witte, K. Wolk, J. Geginat. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 21:5(2010), pp. 331-344.
|Titolo:||Biology of interleukin-10|
|Parole Chiave:||IL-10 family; Cytokine receptor; c-maf; AHR; Foxp3; IL-27|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.cytogfr.2010.09.002|
|Appare nelle tipologie:||01 - Articolo su periodico|