Patients with Philadelphia-negative myeloproliferative neoplasm (MPN) are prone to the development of second cancers, but the factors associated with these events have been poorly explored. In an international nested case-control study, we recruited 647 patients with carcinoma, nonmelanoma skin cancer, hematological second cancer, and melanoma diagnosed concurrently or after MPN diagnosis. Up to 3 control patients without a history of cancer and matched with each case for center, sex, age at MPN diagnosis, date of diagnosis, and MPN disease duration were included (n 5 1234). Cases were comparable to controls for MPN type, driver mutations and cardiovascular risk factors. The frequency of thrombosis preceding MPN was similar for cases and controls (P 5 .462). Thrombotic events after MPN and before second cancer were higher in cases than in controls (11.6% vs 8.1%; P 5 .013), because of a higher proportion of arterial thromboses (6.2% vs 3.7%; P 5 .015). After adjustment for confounders, the occurrence of arterial thrombosis remained independently associated with the risk of carcinoma (odds ratio, 1.97; 95% confidence interval, 1.14-3.41), suggesting that MPN patients experiencing arterial events after MPN diagnosis deserve careful clinical surveillance for early detection of carcinoma.
Arterial thrombosis in Philadelphia-negative myeloproliferative neoplasms predicts second cancer: A case-control study / V. De Stefano, A. Ghirardi, A. Masciulli, A. Carobbio, F. Palandri, N. Vianelli, E. Rossi, S. Betti, A. Di Veroli, A. Iurlo, D. Cattaneo, G. Finazzi, M. Bonifacio, L. Scaffidi, A. Patriarca, E. Rumi, I.C. Casetti, C. Stephenson, P. Guglielmelli, E.M. Elli, M. Palova, D. Rapezzi, D. Erez, M. Gomez, K. Wille, M. Perez-Encinas, F. Lunghi, A. Angona, M.L. Fox, E. Beggiato, G. Benevolo, G. Carli, R. Cacciola, M.F. McMullin, A. Tieghi, V. Recasens, S. Isfort, M. Marchetti, M. Griesshammer, A. Alvarez-Larran, A.M. Vannucchi, A. Rambaldi, T. Barbui. - In: BLOOD. - ISSN 0006-4971. - 135:5(2020 Jan 30), pp. 381-386.
|Titolo:||Arterial thrombosis in Philadelphia-negative myeloproliferative neoplasms predicts second cancer: A case-control study|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||30-gen-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1182/blood.2019002614|
|Appare nelle tipologie:||01 - Articolo su periodico|