Invasive fungal diseases (IFDs), especially pneumocystosis, cryptococcosis, histoplasmosis, and coccidioidomycosis, are increasingly observed among patients with systemic autoimmune diseases. Such patients are susceptible to the abovementioned IFDs because of their disease-related immunological defects and/or concomitant immunosuppressive therapies. The knowledge of the epidemiology of endemic and nonendemic mycoses such as the risk factors for IFDs is crucial for the patient's assessment. A high index of suspicion is mandatory because the diagnosis is often challenging due to potential overlap between the signs and symptoms of the underlying autoimmune disease and the IFD clinical presentation. After appropriate microbiological sample collection, a prompt antifungal treatment is mandatory due to the high mortality of IFDs in immunocompromised patients without appropriate therapy.
Invasive fungal diseases in patients with rheumatic diseases / S. Antinori, A. Giacomelli (HANDBOOK OF SYSTEMIC AUTOIMMUNE DISEASES). - In: Infections in Systemic Autoimmune Diseases: Risk Factors and Management / [a cura di] F. Atzeni, J.B. Galloway, J.J. Gomez-Reino, M. Galli. - [s.l] : Elsevier Ltd, 2020. - ISBN 9780444642172. - pp. 13-48
Invasive fungal diseases in patients with rheumatic diseases
S. Antinori;A. Giacomelli
2020
Abstract
Invasive fungal diseases (IFDs), especially pneumocystosis, cryptococcosis, histoplasmosis, and coccidioidomycosis, are increasingly observed among patients with systemic autoimmune diseases. Such patients are susceptible to the abovementioned IFDs because of their disease-related immunological defects and/or concomitant immunosuppressive therapies. The knowledge of the epidemiology of endemic and nonendemic mycoses such as the risk factors for IFDs is crucial for the patient's assessment. A high index of suspicion is mandatory because the diagnosis is often challenging due to potential overlap between the signs and symptoms of the underlying autoimmune disease and the IFD clinical presentation. After appropriate microbiological sample collection, a prompt antifungal treatment is mandatory due to the high mortality of IFDs in immunocompromised patients without appropriate therapy.File | Dimensione | Formato | |
---|---|---|---|
Invasive fungal diseases.pdf
accesso riservato
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione
392.03 kB
Formato
Adobe PDF
|
392.03 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.