Background While tobacco smoke contains thousands of chemicals, some of which are carcinogenic to humans, the content of electronic cigarette smoke is less known. This work aimed to assess and compare the exposure associated with different smoking habits by profiling urinary mercapturic acids as biomarkers of toxic compounds. Methods In this pilot study, sixty-seven healthy adults with different smoking habits were investigated: 38 non-smokers (NS), 7 electronic cigarette users (ECU), and 22 traditional tobacco smokers (TTS). Seventeen urinary mercapturic acids, metabolites of 1,3-butadiene (DHBMA, MHBMA), 4-chloronitrobenze (NANPC), acrolein (3-HPMA), acrylamide (AAMA, GAMA), acrylonitrile (CEMA), benzene (SPMA), crotonaldehyde (CMEMA, HMPMA), ethylating agents (EMA), methylating agents (MMA), ethylene oxide (HEMA), N,N-dimethylformamide (AMCC), propylene oxide (2-HPMA), styrene (PHEMA), and toluene (SBMA), were quantified, along with urinary nicotine and cotinine. Results Median urinary cotinine was 0.4, 1530 and 1772 µg/L in NS, ECU and TTS, respectively. Most mercapturic acids were 2–165 fold-higher in TTS compared to NS, with CEMA, MHBMA, 3-HPMA and SPMA showing the most relevant increases. Furthermore, some mercapturic acids were higher in ECU than NS; CEMA and 3-HPMA, in particular, showed significant increases and were 1.8 and 4.9 fold-higher, respectively. Conclusions This study confirms that tobacco smoking is a major source of carcinogenic chemicals such as benzene and 1,3-butadiene; electronic cigarette use is a minor source, mostly associated with exposure to chemicals with less carcinogenic potential such as acrylonitrile and acrolein.
Urinary biomonitoring of subjects with different smoking habits. Part I: Profiling mercapturic acids / G. Frigerio, R. Mercadante, L. Campo, E. Polledri, L. Boniardi, L. Olgiati, P. Missineo, S. Fustinoni. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 327(2020 Jul 01), pp. 48-57.
|Titolo:||Urinary biomonitoring of subjects with different smoking habits. Part I: Profiling mercapturic acids|
FRIGERIO, GIANFRANCO (Co-primo)
MERCADANTE, ROSA (Co-primo)
FUSTINONI, SILVIA (Ultimo) (Corresponding)
|Parole Chiave:||Urinary mercapturic acids; Volatile organic compounds; Smoking habit; Tobacco smoking; Electronic cigarette smoking; Biomonitoring;|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||1-lug-2020|
|Data ahead of print / Data di stampa:||10-apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.toxlet.2020.03.010|
|Appare nelle tipologie:||01 - Articolo su periodico|
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