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EnglishOutcomes after transplantation of lungs (LuTX) treated with Ex-Vivo Lung Perfusion (EVLP) are debated. In a single-center 8-years retrospective analysis we compared: donors’ and recipients’ characteristics, gas exchange and lung mechanics at ICU admission, 3, 6 and 12 months, and patients survival of LuTX from Standard donors compared to EVLP treated grafts. 193 LuTX were performed. Thirty-one LuTX, out of 50 EVLP procedures, were carried-out: 7 from non-heart-beating and 24 from extended criteria brain-dead donors. Recipients’ characteristics were similar. At ICU admission, compared to Standard donors, EVLP patients had worse PaO2/FiO2 (276 [206;374] vs. 204 [133;245] mmHg, p<0.05), more frequent extracorporeal support (18 vs. 32%, p=0.053) and longer mechanical ventilation duration (28-days ventilator-free days: 27 [24; 28] vs. 26 [19;27], p<0.05). ICU length of stay (4 [2;9] vs. 6 [3;12] days, p=0.208), 28-days survival (99 vs. 97%, p=0.735) and 1-year respiratory function were similar between groups. Log-rank analysis (median follow-up 2.5 years) demonstrated similar patients survival (p=0.439) and time free of chronic lung allograft disease (p=0.484). The EVLP program increased by 16% the number of LuTX. Compared to Standard donors, EVLP patients had worse respiratory function immediately after LuTX but similar early and mid-term outcomes.
Early Pulmonary Function and Mid Term Outcome in Lung Transplantation after Ex Vivo Lung Perfusion- a single-center, retrospective, observational, cohort study / J. Fumagalli, L. Rosso, F. Gori, L.C. Morlacchi, V. Rossetti, P. Tarsia, F. Blasi, I. Righi, P. Mendogni, A. Palleschi, D. Tosi, G. Bonitta, M. Nosotti, E. Benazzi, V. Scaravilli, F. Valenza, G. Grasselli, A. Zanella. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - (2020). [Epub ahead of print]
| Titolo: | Early Pulmonary Function and Mid Term Outcome in Lung Transplantation after Ex Vivo Lung Perfusion- a single-center, retrospective, observational, cohort study |
| Autori: | GRASSELLI, GIACOMO (Penultimo) ZANELLA, ALBERTO (Ultimo) (Corresponding) |
| Parole Chiave: | Ex-Vivo Lung Perfusion; Lung Transplantation |
| Settore Scientifico Disciplinare: | Settore MED/21 - Chirurgia Toracica Settore MED/41 - Anestesiologia |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Tipologia: | Article (author) |
| Data ahead of print / Data di stampa: | apr-2020 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/tri.13606 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Transpl Int accepted manuscript.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Embargo: 01/04/2021 Richiedi una copia | ||
| tri.13606.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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