In this paper, we describe the synthesis of neglected 1-aminoisochromene derivatives starting from 2-alkynylbenzaldehydes and electron-poor anilines. The domino reaction is catalyzed by original [Ag(I)PcL] complexes and occurs with complete regioselectivity under mild conditions. The approach well-tolerates different aryl, heteroaryl, alkyl and cycloalkyl substituents on alkyne terminus to give the desired products in modest to very good yields.

[Ag(PcL)]-Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Electron-poor Anilines: Synthesis of 1-Aminoisochromenes / V. Pirovano, G. Hamdan, D. Garanzini, E. Brambilla, E. Rossi, A. Caselli, G. Abbiati. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2020:17(2020), pp. 2592-2599. [10.1002/ejoc.202000275]

[Ag(PcL)]-Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Electron-poor Anilines: Synthesis of 1-Aminoisochromenes

V. Pirovano
Primo
;
D. Garanzini;E. Brambilla;E. Rossi;A. Caselli
Penultimo
;
G. Abbiati
Ultimo
2020

Abstract

In this paper, we describe the synthesis of neglected 1-aminoisochromene derivatives starting from 2-alkynylbenzaldehydes and electron-poor anilines. The domino reaction is catalyzed by original [Ag(I)PcL] complexes and occurs with complete regioselectivity under mild conditions. The approach well-tolerates different aryl, heteroaryl, alkyl and cycloalkyl substituents on alkyne terminus to give the desired products in modest to very good yields.
Isochromenes; Alkynes; Domino reactions; Silver; Electron-poor anilines; Macrocyclic ligands
Settore CHIM/06 - Chimica Organica
Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/725902
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