Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution H-1 NMR-spectroscopy.Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.
Congenital pulmonary malformations : metabolomic profile of lung phenotype in infants / G. Pelizzo, M.C. Mimmi, M. Ballico, M. Marotta, I. Goruppi, J.L. Peiro, E. Zambaiti, F. Costanzo, E. Andreatta, E. Tonin, V. Calcaterra. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 29:1(2016), pp. 143-147. [10.3109/14767058.2014.991708]
Congenital pulmonary malformations : metabolomic profile of lung phenotype in infants
G. Pelizzo
;
2016
Abstract
Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution H-1 NMR-spectroscopy.Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.File | Dimensione | Formato | |
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