Statins and sildenafil have been shown to exert beneficial effects in cardiac injury. We hypothesized that antenatal maternal administration of simvastatin and/or sildenafil might also promote benefits in cardiac remodeling of congenital diaphragmatic hernia (CDH). Therefore, we performed micro-CT image analysis and histology of the heart after antennal treatment in experimental nitrofen-induced CDH.
Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model / G. Pelizzo, R. Bussani, E. Mazzon, C. Anfuso, C. Lombardi, V. Zambelli, L. Zandonà, A. De Silvestri, F. Zennaro, V. Calcaterra. - In: FETAL DIAGNOSIS AND THERAPY. - ISSN 1015-3837. - 46:1(2019), pp. 28-37. [10.1159/000490144]
Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model
G. Pelizzo
Primo
;
2019
Abstract
Statins and sildenafil have been shown to exert beneficial effects in cardiac injury. We hypothesized that antenatal maternal administration of simvastatin and/or sildenafil might also promote benefits in cardiac remodeling of congenital diaphragmatic hernia (CDH). Therefore, we performed micro-CT image analysis and histology of the heart after antennal treatment in experimental nitrofen-induced CDH.
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Pelizzo et al, 2017.pdf
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Pelizzo et al, 2019.pdf
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