The role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has been reported to protect cells from apoptosis activation but also to sensitize cells to apoptotic stimuli. We have previously demonstrated that the down-regulation of Myc protein activates apoptosis in melanoma cells and increases the susceptibility of cells to various antitumoral treatments. Beyond the well-known role in the G1→S transition, MYC is also involved in the G2-M cell cycle phases regulation.
MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel / G. Gatti, G. Maresca, M. Natoli, F. Florenzano, A. Nicolin, A. Felsani, I. D'Agnano. - In: PLOS ONE. - ISSN 1932-6203. - 4:5(2009).
|Titolo:||MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel|
GATTI, GIULIANA (Primo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0005442|
|Appare nelle tipologie:||01 - Articolo su periodico|