Neuroendocrine neoplasms (NENs) are a group of tumors originating from the neuroendocrine system. They mainly occur in the digestive system and the respiratory tract. It is well-know a strict interaction between neuroendocrine system and inflammation, which can play an important role in NEN carcinogenesis. Inflammatory mediators, which are produced by the tumor microenvironment, can favor cancer induction and progression, and can promote immune editing. On the other hand, a balanced immune system represents a relevant step in cancer prevention through the elimination of dysplastic and cancer cells. Therefore, an inflammatory response may be both pro- and anti-tumorigenic. In this review, we provide an overview concerning the complex interplay between inflammation and gastroenteropancreatic NENs, focusing on the tumorigenesis and clinical implications in these tumors.
Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications / G. Vitale, S. Carra, F. Ferrau, E. Guadagno, A. Faggiano, A. Colao. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - 146(2020), pp. 102840.1-102840.12.
|Titolo:||Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications|
VITALE, GIOVANNI (Primo) (Corresponding)
|Parole Chiave:||Neuroendocrine tumors; Inflammation; Tumor microenvironment; Immune system; Cytokines|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||2020|
|Data ahead of print / Data di stampa:||23-dic-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.critrevonc.2019.102840|
|Appare nelle tipologie:||01 - Articolo su periodico|