Purpose: To test the association between African-American race and overall mortality (OM) rates in patients with metastatic renal cell carcinoma (mRCC). Methods: Within the Surveillance, Epidemiology, and End Results registry (2006–2015), we identified patients with clear cell (ccmRCC) and non-clear cell mRCC (non-ccmRCC). African-Americans, Caucasians, and Hispanics were identified. Stratification was made according to histology and treatments: (1) no treatment, (2) systemic therapy (ST), (3) cytoreductive nephrectomy (CNT), (4) CNT + ST. Kaplan–Meier plots and multivariable Cox regression analyses were used. Results: Of ccmRCC patients, 410 (7%), 4353 (75%), and 1005 (17%) were African-American, Caucasian, and Hispanic, respectively. Of non-ccmRCC patients, 183 (25%), 479 (65%), and 77 (10%) were African-American, Caucasian, and Hispanic, respectively. In ccmRCC, African-Americans were associated with higher OM rates (HR 1.20; 95% CI 1.05–1.37). Conversely, in non-ccmRCC, African-Americans were associated with lower OM rates (HR 0.75; 95% CI 0.59–0.97). Conclusion: African-American race is associated with prolonged survival in non-ccmRCC, but it is also associated with lower survival rates in ccmRCC. The exception to these observations consisted of patients treated with combination of CNT + ST for either ccmRCC or non-ccmRCC.
Racial and ethnic differences in survival in contemporary metastatic renal cell carcinoma patients, according to alternative treatment modalities / S. Luzzago, C. Palumbo, G. Rosiello, S. Knipper, A. Pecoraro, S. Nazzani, Z. Tian, G. Musi, E. Montanari, S.F. Shariat, F. Saad, A. Briganti, O. de Cobelli, P.I. Karakiewicz. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 31:3(2020), pp. 263-272.
|Titolo:||Racial and ethnic differences in survival in contemporary metastatic renal cell carcinoma patients, according to alternative treatment modalities|
LUZZAGO, STEFANO (Primo) (Corresponding)
DE COBELLI, OTTAVIO (Penultimo)
|Parole Chiave:||African-American; Caucasian; Cytoreductive nephrectomy; Hispanic; Metastatic renal cell carcinoma; Systemic therapy|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10552-020-01270-8|
|Appare nelle tipologie:||01 - Articolo su periodico|
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