Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy.
Cell Based Therapy for Duchenne Muscular Dystrophy [Recensione] / A. Farini, P. Razini, S. Erratico, Y. Torrente, M. Meregalli. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - 221:3(2009 Aug 17), pp. 526-534.
Cell Based Therapy for Duchenne Muscular Dystrophy
A. FariniPrimo
;P. RaziniSecondo
;S. Erratico;Y. TorrentePenultimo
;M. MeregalliUltimo
2009
Abstract
Mutations in the dystrophin gene cause an X-linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy.Pubblicazioni consigliate
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