Standard anti-cancer therapies promote tumor growth suppression mainly via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Paraptosis is a new form of programmed cell death displaying endoplasmic reticulum (ER) and/or mitochondria dilation, generally due to proteostasis disruption or redox and ion homeostasis alteration. Recent studies have highlighted that several natural compounds can trigger paraptosis in different tumor cell lines. Here, we review the molecular mechanisms underlying paraptotic cell death, as well as the natural products inducing this kind of cell death program. A better understanding of paraptosis should facilitate the development of new therapeutic strategies for cancer prevention and treatment.

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds / F. Fontana, M. Raimondi, M. Marzagalli, A. Di Domizio, P. Limonta. - In: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. - ISSN 0304-419X. - 1873:2(2020), pp. 188338.1-188338.11. [10.1016/j.bbcan.2020.188338]

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds

F. Fontana
Primo
;
M. Raimondi
Secondo
;
M. Marzagalli;P. Limonta
Ultimo
2020

Abstract

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Paraptosis is a new form of programmed cell death displaying endoplasmic reticulum (ER) and/or mitochondria dilation, generally due to proteostasis disruption or redox and ion homeostasis alteration. Recent studies have highlighted that several natural compounds can trigger paraptosis in different tumor cell lines. Here, we review the molecular mechanisms underlying paraptotic cell death, as well as the natural products inducing this kind of cell death program. A better understanding of paraptosis should facilitate the development of new therapeutic strategies for cancer prevention and treatment.
Paraptosis; Apoptosis; Programmed cell death; Natural compounds; Novel therapeutic strategies
Settore BIO/13 - Biologia Applicata
2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
Revised manuscript.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 1.06 MB
Formato Adobe PDF
1.06 MB Adobe PDF Visualizza/Apri
1-s2.0-S0304419X19301945-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 1.03 MB
Formato Adobe PDF
1.03 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/715217
Citazioni
  • ???jsp.display-item.citation.pmc??? 57
  • Scopus 112
  • ???jsp.display-item.citation.isi??? 107
social impact