Styrene-block-(ethylene-co-butylene)-block-styrene (SEBS) copolymers are biocompatible elastomers with outstanding stability to UV radiation. This work addresses the potentialities of this class of elastomers for the development of transdermal patches. The influence of SEBS molecular weight, plasticizer and tackifier type on rheological pattern, debonding mechanisms, adhesive properties (i.e., tack, shear and peel adhesion) as well as on the in vitro biopharmaceutical performances (i.e., drug release and skin permeability) was investigated using ibuprofen as model drug. The relationships between the linear and non-linear rheological properties and the main adhesive and biopharmaceutical properties of the prepared patches have been demonstrated. The higher the viscous component of the matrix, the lower its cohesiveness and the faster the drug release rate. The in vitro skin permeability of ibuprofen was not limited by the polymeric matrix, even if compared to the commercial reference product. In conclusion, SEBS copolymers are suitable materials to design drug in-adhesive patches. In particular, SEBS-low molecular weight is the polymer worthy of consideration because of its favorable viscoelastic behavior.
SEBS block copolymers as novel materials to design transdermal patches / C. Gennari, G. Quaroni, C. Creton, P. Minghetti, F. Cilurzo. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 15(2020 Feb 15).
|Titolo:||SEBS block copolymers as novel materials to design transdermal patches|
GENNARI, CHIARA GRAZIA MILENA (Co-primo)
QUARONI, GAIA MARIA GIORGIA (Co-primo)
MINGHETTI, PAOLA (Penultimo)
CILURZO, FRANCESCO (Ultimo) (Corresponding)
|Parole Chiave:||SEBS; Pressure-sensitive adhesives; Transdermal patches; Rheology; Skin permeation; Drug release;|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||15-feb-2020|
|Data ahead of print / Data di stampa:||dic-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ijpharm.2019.118975|
|Appare nelle tipologie:||01 - Articolo su periodico|
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