Background: Maize allergy is not very common especially in Europe. The number of studies that address IgE mediated maize allergy is all too few. Objective: Evaluate subjects with a history of maize allergy by double-blind, placebo-controlled food challenge; identify the spectrum of symptoms manifested during challenge; determine the lowest provocation dose (PD) during challenge; determine the performance characteristics of maize skin prick test and specific IgE. Methods: Twenty-seven patients with a history of maize allergy were enrolled to be evaluated by skin test, specific IgE and double-blind placebo-controlled maize challenge. Results Forty-eight percent of the patients were challenge positive. PD range was 0.1-25 g. Fifty-four percent of the maize allergic subjects had a PD that was ≤2.5 g; two subjects reacted to 100 mg of maize. Comparison of maize specific IgE levels and skin test results to the challenge results revealed the following (specific IgE level/skin testing): sensitivity 1.00/0.846, specificity 0.077/0.384, positive predictive value 0.520/0.579, and negative predictive value 1.00/0.714. Conclusion: Maize is a cause of IgE-mediated allergic reactions to foods in adults and children. Nearly half of the subjects recruited were confirmed by challenge to be allergic to maize. Twenty-three percent of the positive challenge patients manifested symptoms that involved two organ systems, thus fulfilling the criteria for maize induced anaphylaxis. Maize is allergenic and can pose a risk for symptomatic food allergy at a dose of 100 mg.
|Titolo:||Maize food allergy : a double-blind placebo-controlled study|
PASTORELLO, ELIDE ANNA (Secondo)
|Parole Chiave:||Allergy symptoms; Anaphylaxis; Corn allergy; Double-blind; Food allergy; Hypersensitivity; Maize allergy; Performance characteristics; Placebo-controlled food challenge; Provocation dose|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||10.1111/j.1365-2222.2008.03094.x|
|Appare nelle tipologie:||01 - Articolo su periodico|