Background: The aim of this study was to test, through a chronobiologic approach, the existence of a significant circannual rhythm of tics and obsessive-compulsive symptoms in patients with Obsessive-Compulsive Tic Disorder (OCTD). The chronotype effect on tics and OC symptoms during seasons was also studied. Methods: Patients with a diagnosis of OCTD (N = 37; mean age = 18.78 ± 8.61) underwent four clinical evaluations: Winter (WIN), Spring (SPR), Summer (SUM) and Autumn (AUT). Tics were evaluated through Yale Global Tic Severity Scale (YGTSS) and OC symptoms through Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Patients’ chronotype was assessed by the Horne-Ostberg morningness-eveningness questionnaire (MEQ), which categorizes subjects according to the individuals'chronotype, being morning-type, evening-type, and neither-type. Results: A statistically significant circannual rhythm was observed for OC symptoms (p = 0.007), with the acrophase occurring between AUT and WIN. Y-BOCS differed along the year (p = 0.0003 and η2p = 0.40) with lower results in SUM compared to WIN (p < 0.05) and AUT (p < 0.01). Tics displayed no circannual rhythm and YGTSS scores were comparable among seasons. Patients were classified as 15 morning-types (40.5%) 15 neither-types (40.5%) and 7 evening-types (19.0%). YGTSS data were similar for all chronotypes while Y-BOCS results were greater during SUM in evening-types than morning-type patients (p < 0.05; 15.7 ± 5.2 vs 3.4 ± 6.0). Limitations: It is essential to investigate the existence of tics and OC symptoms circannual rhythms over the course of more than one year with a larger sample. Conclusions: OC symptoms displayed a significant circannual rhythm and were influenced by patients’ chronotype. On the contrary, tics resulted similar among seasons and chronotypes.
Exploring circannual rhythms and chronotype effect in patients with Obsessive-Compulsive Tic Disorder (OCTD) : a pilot study / J.A. Vitale, M. Briguglio, R. Galentino, B. Dell'Osso, A. Malgaroli, G. Banfi, M. Porta. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 262(2020 Feb 01), pp. 286-292.
|Titolo:||Exploring circannual rhythms and chronotype effect in patients with Obsessive-Compulsive Tic Disorder (OCTD) : a pilot study|
BRIGUGLIO, MATTEO (Secondo) (Corresponding)
|Parole Chiave:||Chronobiology; Chronotype; Circannual Rhythm; OCTD; Tic|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/25 - Psichiatria
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
|Data di pubblicazione:||1-feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jad.2019.11.040|
|Appare nelle tipologie:||01 - Articolo su periodico|