In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i. e. enfuvirtide in the first case and etravirine in the second one.

Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports / L. Taramasso, C. Dentone, A. Alessandrini, B. Bruzzone, G. Icardi, R. Garraffo, I. De Macina, C. Viscoli, A. Di Biagio. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - 24:11(2015 Oct 24), pp. 831-834. [10.1177/0956462414556330]

Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

L. Taramasso
Primo
;
2015

Abstract

In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i. e. enfuvirtide in the first case and etravirine in the second one.
HIV; AIDS; antiretroviral therapy; treatment; dolutegravir; darunavir; treatment experienced; resistance
Settore MED/17 - Malattie Infettive
24-ott-2015
Article (author)
File in questo prodotto:
File Dimensione Formato  
38 Taramasso L et al.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 175.71 kB
Formato Adobe PDF
175.71 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/708355
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact