In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i. e. enfuvirtide in the first case and etravirine in the second one.
Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports / L. Taramasso, C. Dentone, A. Alessandrini, B. Bruzzone, G. Icardi, R. Garraffo, I. De Macina, C. Viscoli, A. Di Biagio. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - 24:11(2015 Oct 24), pp. 831-834. [10.1177/0956462414556330]
Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports
L. TaramassoPrimo
;
2015
Abstract
In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i. e. enfuvirtide in the first case and etravirine in the second one.File | Dimensione | Formato | |
---|---|---|---|
38 Taramasso L et al.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
175.71 kB
Formato
Adobe PDF
|
175.71 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.