HIV-1 has developed several strategies to evade natural killer (NK)-cell antiviral functions. One of these mechanisms is the HIV-1-induced expansion of highly dysfunctional NK-cell subsets. Here, we analyze a large cohort of HIV-1-infected patients in early or chronic phases of infection, both cross-sectionally and longitudinally. We demonstrate that a striking decrease in the surface expression of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7) represents the earliest marker of the aberrant NK-cell dysregulation, which precedes the down-modulation of CD56 mostly occurring in patients with chronic HIV-1 viremia. The combined detection of Siglec-7 and CD56 allows the identification of 2 new pathologic NK-cell subsets expanded preferentially in early (Siglec-7-/CD56+) or chronic (Siglec-7-/ CD56+) stages of HIV-1 infection. Remarkably, these phenotypic abnormalities were directly associated with progressive and distinct impairments of NK-cell functions. The aforementioned NK-cell aberrancies could be observed only in the presence of high levels of viral replication and not in patients with low or undetectable HIV-1 viremia, such as long-term nonprogressors or patients having undergone antiretroviral therapy. High frequencies of Siglec-7-/CD56+ and Siglec-7-/CD56+ pathologic NK cells reflect the immune and clinical status of HIV-1 infection and can also track the effectiveness of therapy.
Quality of Life in Myelodysplastic Syndromes and Physicians' Perception / E.N. Oliva, V. Santini, A. Poloni, V. Liso, D. Cilloni, A. Terenzi, P. Guglielmo, R. Ghio, A. Cortelezzi, G. Semenzato, C. Clissa, F. Salvi, O. Villani, M.A. Aloe Spiriti. - In: BLOOD. - ISSN 0006-4971. - 114:22(2009), pp. 3822-3822. ((Intervento presentato al 51. convegno Annual Meeting of the American Society of Haematology tenutosi a New Orleans nel 2009.
|Titolo:||Quality of Life in Myelodysplastic Syndromes and Physicians' Perception|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1182/blood-2009-06-226332|
|Appare nelle tipologie:||01 - Articolo su periodico|