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AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishOBJECTIVES: Some controversy exists for the potential association of the plasminogen activator inhibitor-1 (PAI-1) gene polymorphism 4G/5G and susceptibility to endometriosis. To clarify this issue, we have examined the prevalence of this polymorphism in a case-control study in the Italian population. STUDY DESIGN: The PAI-1 4G/5G polymorphism was evaluated in n=368 reproductive year aged Caucasian women who underwent gynaecological laparoscopy for chronic pelvic pain, infertility, ovarian cysts and myomas. A second group of controls included n=329 normal subjects. RESULTS: The 697 women enrolled were divided as follows: the endometriosis group (n=204), the gynaecological control group (n=164) and the general population control group (n=329). No statistical significant differences emerged between endometriosis patients and gynaecological controls with regard to the allele frequencies and co-dominant and dominant models of genotype distribution. A borderline statistical difference was only observed for the recessive model of inheritance in which, contrary to previous findings, the PAI-1 4G/4G genotype seems to be less linked to the disease development. CONCLUSION: The findings reported herein do not support the previously reported data indicating a greater susceptibility to endometriosis in patients harbouring the PAI-1 4G/5G and 4G/4G genotypes and exclude a significant role of polymorphism in endometriosis development.
Plasminogen activator inhibitor-1 4G/5G polymorphism and susceptibility to endometriosis in the Italian population / D. Gentilini, P. Vigano, D. Castaldi, D. Mari, M. Busacca, P. Vercellini, E. Somigliana, A.M. Di Blasio. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 146:2(2009 Oct), pp. 219-221.
| Titolo: | Plasminogen activator inhibitor-1 4G/5G polymorphism and susceptibility to endometriosis in the Italian population |
| Autori: | GENTILINI, DAVIDE (Primo) VIGANO', PAOLA (Secondo) SOMIGLIANA, EDGARDO (Penultimo) |
| Parole Chiave: | Endometriosis; Plasminogen activator inhibitor-1; Polymorphism |
| Settore Scientifico Disciplinare: | Settore MED/40 - Ginecologia e Ostetricia |
| Data di pubblicazione: | ott-2009 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejogrb.2009.06.008 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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