BACKGROUND AND AIMS: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. METHODS: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline, and 86 cardiovascular-related proteins were analyzed. In the PIVUS study only, IMT-CCA and IMT-bulb were investigated in relation to incident atherosclerotic disease over 10 years of follow-up. RESULTS: In a meta-analysis of the analysis performed separately in the cohorts, three proteins, matrix metalloproteinase-12 (MMP-12), hepatocyte growth factor (HGF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), were associated with IMT-CCA when adjusted for traditional cardiovascular risk factors. Five proteins were associated with IMT-bulb (MMP-12, growth/differentiation factor 15 (GDF-15), osteoprotegerin, growth hormone and renin). Following adjustment for cardiovascular risk factors, IMT-bulb was significantly more closely related to incident stroke or myocardial infarction (total number of cases, 111) than IMT-CCA in the PIVUS study (HR 1.51 for 1 SD, 95%CI 1.21-1.87, p < 0.001 vs HR 1.17, 95%CI 0.93-1.47, p = 0.16). MMP-12 levels were related to this combined end-point (HR 1.30, 95%CI 1.08-1.56, p = 0.0061). CONCLUSIONS: Elevated levels of MMP-12 were associated with both IMT-CCA and IMT-bulb, but other proteins were significantly related to IMT in only one of these locations. The finding that IMT-bulb was more closely related to incident atherosclerotic disease than IMT-CCA emphasizes a difference between these measurements of IMT.
The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : a meta-analysis and a longitudinal evaluation / L. Lind, B. Gigante, Y. Borne, A. Mälarstig, J. Sundström, J. Ärnlöv, E. Ingelsson, D. Baldassarre, E. Tremoli, F. Veglia, A. Hamsten, M. Orho-Melander, J. Nilsson, O. Melander, G. Engström. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 295(2020 Feb), pp. 25-30.
|Titolo:||The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : a meta-analysis and a longitudinal evaluation|
|Parole Chiave:||Atherosclerosis; Carotid artery; Meta-analysis; Proteomics; Ultrasound|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.atherosclerosis.2020.01.011|
|Appare nelle tipologie:||01 - Articolo su periodico|