The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Kondo, K.; Van Schil, P.; Detterbeck, F.C.; Okumura, M.; Giroux, D.; Asamura, H.; Crowley, J.; Falkson, C.; Filosso, P.L.; Giaccone, G.; Huang, J.; Kim, J.; Lucchi, M.; Marino, M.; Marom, E.M.; Nicholson, A.G.; Ruffini, E.; Goldstraw, P.; Rami-Porta, R.; Ball, D.; Beer, D.; Beyruti, R.; Bolejack, V.; Chansky, K.; Eberhardt, W.E.E.; Edwards, J.; Galateau-Salle, F.; Gleeson, F.; Groome, P.; Kennedy, C.; Kingsbury, L.; Kim, Y.T.; Kondo, H.; Krasnik, M.; Kubota, K.; Lerut, A.; Lyons, G.; Van Meerbeeck, J.; Mitchell, A.; Nakano, T.; Nowak, A.; Peake, M.; Rice, T.; Rosenzweig, K.; Rusch, V.; Saijo, N.; Sculier, J.-.; Shemanski, L.; Stratton, K.; Suzuki, K.; Tachimori, Y.; Thomas, C.F.; Travis, W.; Tsao, M.S.; Turrisi, A.; Vansteenkiste, J.; Watanabe, H.; Y. -L., W.; Baas, P.; Erasmus, J.; Hasegawa, S.; Inai, K.; Kernstine, K.; Kindler, H.; Krug, L.; Nackaerts, K.; Pass, H.; Rice, D.; Blackstone, E.; Call Caja, S.; Ahmad, U.; Detterbeck, F.; Girard, N.; Haam, S.J.; Gomez, D.R.; Bae, M.K.; Strobel, P.; Marx, A.; Saita, S.; Wakelee, H.; Bertolaccini, L.; Vallieres, E.; Scott, W.; Su, S.; Park, B.; Marks, J.; Khella, S.; Shen, R.; Rosenberg, M.; Tomulescu, V.; Foroulis, C.; Lang-Lazdunski, L.; Bille, A.; Maessen, J.G.; Keijzers, M.; Van Veer, H.; Wright, C.; Facciolo, F.; Palmieri, G.; Buonerba, C.; Ferguson, M.; Marulli, G.; Loehrer, P.; Kalkat, M.; Rohrberg, K.; Daugaard, G.; Toker, A.; Erus, S.; Kimmich, M.; Brunelli, A.; Refai, M.; Nicholson, A.; Lim, E.; Park, I.K.; Wagner, J.; Tieu, B.; Fang, W.; Zhang, J.; Yu, Z.; Han, Y.; Li, Y.; Chen, K.; Chen, G.; Nagai, K.; Fujii, Y.; Nakajima, J.; Ikeda, N.; Haraguchi, S.; Onuki, T.; Yoshino, I.; Tsuchida, M.; Takahashi, S.; Yokoi, K.; Hanyuda, M.; Niwa, H.; Date, H.; Maniwa, Y.; Miyoshi, S.; Iwasaki, A.; Okamoto, T.; Nagayasu, T.; Tanaka, F.; Suzuki, M.; Yoshida, K.; Okuma, Y.; Horio, H.; Matsumura, A.; Higashiyama, M.; Suehisa, H.; Onuki, T.; Sano, Y.; Kondo, K.; Al Kattan, K.; Cerfolio, R.; Gebitekin, C.; Gomez De Antonio, D.; Kernstine, K.H.; Altorki, N.; Novoa, N.; Scarci, M.; Voltolini, L.; Weder, W.; Zurek, W.; Arame, A.; Casadio, C.; Carbognani, P.; Donati, G.; Keshavjee, S.; Klepetko, W.; Moser, B.; Lequaglie, C.; Liberman, M.; Mancuso, M.; Nosotti, M.; Spaggiari, L.; Thomas, P.A.; Rendina, E.; Venuta, F.; Anile, M.; Schutzner, J.; Rocco, G.

doi:10.1097/JTO.0000000000000291

Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors / K. Kondo, P. Van Schil, F.C. Detterbeck, M. Okumura, D. Giroux, H. Asamura, J. Crowley, C. Falkson, P.L. Filosso, G. Giaccone, J. Huang, J. Kim, M. Lucchi, M. Marino, E.M. Marom, A.G. Nicholson, E. Ruffini, P. Goldstraw, R. Rami-Porta, D. Ball, D. Beer, R. Beyruti, V. Bolejack, K. Chansky, W.E.E. Eberhardt, J. Edwards, F. Galateau-Salle, F. Gleeson, P. Groome, C. Kennedy, L. Kingsbury, Y.T. Kim, H. Kondo, M. Krasnik, K. Kubota, A. Lerut, G. Lyons, J. Van Meerbeeck, A. Mitchell, T. Nakano, A. Nowak, M. Peake, T. Rice, K. Rosenzweig, V. Rusch, N. Saijo, J.-. Sculier, L. Shemanski, K. Stratton, K. Suzuki, Y. Tachimori, C.F. Thomas, W. Travis, M.S. Tsao, A. Turrisi, J. Vansteenkiste, H. Watanabe, Y.-. Wu, P. Baas, J. Erasmus, S. Hasegawa, K. Inai, K. Kernstine, H. Kindler, L. Krug, K. Nackaerts, H. Pass, D. Rice, E. Blackstone, S. Call Caja, U. Ahmad, F. Detterbeck, N. Girard, S.J. Haam, D.R. Gomez, M.K. Bae, P. Strobel, A. Marx, S. Saita, H. Wakelee, L. Bertolaccini, E. Vallieres, W. Scott, S. Su, B. Park, J. Marks, S. Khella, R. Shen, M. Rosenberg, V. Tomulescu, C. Foroulis, L. Lang-Lazdunski, A. Bille, J.G. Maessen, M. Keijzers, H. Van Veer, C. Wright, F. Facciolo, G. Palmieri, C. Buonerba, M. Ferguson, G. Marulli, P. Loehrer, M. Kalkat, K. Rohrberg, G. Daugaard, A. Toker, S. Erus, M. Kimmich, A. Brunelli, M. Refai, A. Nicholson, E. Lim, I.K. Park, J. Wagner, B. Tieu, W. Fang, J. Zhang, Z. Yu, Y. Han, Y. Li, K. Chen, G. Chen, K. Nagai, Y. Fujii, J. Nakajima, N. Ikeda, S. Haraguchi, T. Onuki, I. Yoshino, M. Tsuchida, S. Takahashi, K. Yokoi, M. Hanyuda, H. Niwa, H. Date, Y. Maniwa, S. Miyoshi, A. Iwasaki, T. Okamoto, T. Nagayasu, F. Tanaka, M. Suzuki, K. Yoshida, Y. Okuma, H. Horio, A. Matsumura, M. Higashiyama, H. Suehisa, T. Onuki, Y. Sano, K. Kondo, K. Al Kattan, R. Cerfolio, C. Gebitekin, D. Gomez De Antonio, K.H. Kernstine, N. Altorki, N. Novoa, M. Scarci, L. Voltolini, W. Weder, W. Zurek, A. Arame, C. Casadio, P. Carbognani, G. Donati, S. Keshavjee, W. Klepetko, B. Moser, C. Lequaglie, M. Liberman, M. Mancuso, M. Nosotti, L. Spaggiari, P.A. Thomas, E. Rendina, F. Venuta, M. Anile, J. Schutzner, G. Rocco. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 9:9(2014), pp. S81-S87.

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors

Kondo K.;Van Schil P.;Detterbeck F. C.;Okumura M.;Giroux D.;Asamura H.;Crowley J.;Falkson C.;Filosso P. L.;Giaccone G.;Huang J.;Kim J.;Lucchi M.;Marino M.;Marom E. M.;Nicholson A. G.;Ruffini E.;Goldstraw P.;Rami-Porta R.;Ball D.;Beer D.;Beyruti R.;Bolejack V.;Chansky K.;Eberhardt W. E. E.;Edwards J.;Galateau-Salle F.;Gleeson F.;Groome P.;Kennedy C.;Kingsbury L.;Kim Y. T.;Kondo H.;Krasnik M.;Kubota K.;Lerut A.;Lyons G.;Van Meerbeeck J.;Mitchell A.;Nakano T.;Nowak A.;Peake M.;Rice T.;Rosenzweig K.;Rusch V.;Saijo N.;Sculier J. -P.;Shemanski L.;Stratton K.;Suzuki K.;Tachimori Y.;Thomas C. F.;Travis W.;Tsao M. S.;Turrisi A.;Vansteenkiste J.;Watanabe H.;Wu Y. -L.;Baas P.;Erasmus J.;Hasegawa S.;Inai K.;Kernstine K.;Kindler H.;Krug L.;Nackaerts K.;Pass H.;Rice D.;Blackstone E.;Call Caja S.;Ahmad U.;Detterbeck F.;Girard N.;Haam S. J.;Gomez D. R.;Bae M. K.;Strobel P.;Marx A.;Saita S.;Wakelee H.;L. Bertolaccini;Vallieres E.;Scott W.;Su S.;Park B.;Marks J.;Khella S.;Shen R.;Rosenberg M.;Tomulescu V.;Foroulis C.;Lang-Lazdunski L.;Bille A.;Maessen J. G.;Keijzers M.;Van Veer H.;Wright C.;Facciolo F.;Palmieri G.;Buonerba C.;Ferguson M.;Marulli G.;Loehrer P.;Kalkat M.;Rohrberg K.;Daugaard G.;Toker A.;Erus S.;Kimmich M.;Brunelli A.;Refai M.;Nicholson A.;Lim E.;Park I. K.;Wagner J.;Tieu B.;Fang W.;Zhang J.;Yu Z.;Han Y.;Li Y.;Chen K.;Chen G.;Nagai K.;Fujii Y.;Nakajima J.;Ikeda N.;Haraguchi S.;Onuki T.;Yoshino I.;Tsuchida M.;Takahashi S.;Yokoi K.;Hanyuda M.;Niwa H.;Date H.;Maniwa Y.;Miyoshi S.;Iwasaki A.;Okamoto T.;Nagayasu T.;Tanaka F.;Suzuki M.;Yoshida K.;Okuma Y.;Horio H.;Matsumura A.;Higashiyama M.;Suehisa H.;Onuki T.;Sano Y.;Kondo K.;Al Kattan K.;Cerfolio R.;Gebitekin C.;Gomez De Antonio D.;Kernstine K. H.;Altorki N.;Novoa N.;Scarci M.;Voltolini L.;Weder W.;Zurek W.;Arame A.;Casadio C.;Carbognani P.;Donati G.;Keshavjee S.;Klepetko W.;Moser B.;Lequaglie C.;Liberman M.;Mancuso M.;M. Nosotti;L. Spaggiari;Thomas P. A.;Rendina E.;Venuta F.;Anile M.;Schutzner J.;Rocco G.

2014

Abstract

Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).

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Scheda completa

Scheda completa (DC)

	Parole chiave
	
				Staging; Prognosis; Thymoma; Thymic carcinoma; Stage classification
			
	Settori scientifico-disciplinari dell'articolo (sola visualizzazione)
	
				Settore MED/21 - Chirurgia Toracica
			
	Data di pubblicazione
	
				2014
			
	Rivista in ANCE
	
				JOURNAL OF THORACIC ONCOLOGY
			
	DOI
	
				https://dx.doi.org/10.1097/JTO.0000000000000291
			
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				Article (author)
			
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				01 - Articolo su periodico

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