Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Results: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). Conclusions: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients’ adherence allowing timely intervention to improve optimal treatment for these patients.
Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children : data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) / C. Centonze, C. Guzzetti, G. Orlando, S. Loche, C. Angeletti, F. Antoniazzi, S. Bernasconi, G.M. Cardinale, M. Caruso-Nicoletti, L. Cavallo, S. Cianfarani, G. Citro, F. De Luca, S. Della Casa, M. Di Pietro, P. Garofalo, C. Giordano, N.A. Greggio, M.R. Licenziati, M. Maghnie, M. Parpagnoli, L. Persani, S. Pesce, M. Sacco, M. Salerno, L. Tafi. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 42:10(2019 Oct), pp. 1241-1244.
|Titolo:||Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children : data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)|
|Parole Chiave:||Children; ECOS; GHD; Growth hormone; Short stature|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||ott-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s40618-019-01046-1|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Centonze2019_Article_AdherenceToGrowthHormoneGHTher.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|