It is widely recognized that the microorganisms inhabiting our gastrointestinal tract—the gut microbiota—deeply affect the pathophysiology of the host. Gut microbiota composition is mostly modulated by diet, and gut microorganisms communicate with the different organs and tissues of the human host by synthesizing hormones and regulating their release. Herein, we will provide an updated review on the most important classes of gut microbiota-derived hormones and their sensing by host receptors, critically discussing their impact on host physiology. Additionally, the debated interplay between microbial hormones and the development of cardiovascular disease will be thoroughly analysed and discussed.

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Titolo: The gut microbiota affects host pathophysiology as an endocrine organ : a focus on cardiovascular disease
Autori: 
BUSNELLI, MARCO (Co-primo) (Corresponding)
MANZINI, STEFANO (Co-primo)
CHIESA, GIULIA MARIA (Ultimo) (Corresponding)
Parole Chiave: Atherosclerosis; Bile acids; Cardiovascular disease; Gut microbiota; Hormones; Metabolism; Neurohormones; SCFA
Settore Scientifico Disciplinare: Settore BIO/14 - Farmacologia
Data di pubblicazione: gen-2020
Rivista: 
NUTRIENTS  
Tipologia: Article (author)
Data ahead of print / Data di stampa: 27-dic-2019
Digital Object Identifier (DOI): http://dx.doi.org/10.3390/nu12010079
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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2434/705556
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