It is widely recognized that the microorganisms inhabiting our gastrointestinal tract—the gut microbiota—deeply affect the pathophysiology of the host. Gut microbiota composition is mostly modulated by diet, and gut microorganisms communicate with the different organs and tissues of the human host by synthesizing hormones and regulating their release. Herein, we will provide an updated review on the most important classes of gut microbiota-derived hormones and their sensing by host receptors, critically discussing their impact on host physiology. Additionally, the debated interplay between microbial hormones and the development of cardiovascular disease will be thoroughly analysed and discussed.
The gut microbiota affects host pathophysiology as an endocrine organ : a focus on cardiovascular disease / M. Busnelli, S. Manzini, G. Chiesa. - In: NUTRIENTS. - ISSN 2072-6643. - 12:1(2020 Jan), pp. 79.1-79.32.
|Titolo:||The gut microbiota affects host pathophysiology as an endocrine organ : a focus on cardiovascular disease|
BUSNELLI, MARCO (Co-primo) (Corresponding)
MANZINI, STEFANO (Co-primo)
CHIESA, GIULIA MARIA (Ultimo) (Corresponding)
|Parole Chiave:||Atherosclerosis; Bile acids; Cardiovascular disease; Gut microbiota; Hormones; Metabolism; Neurohormones; SCFA|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||gen-2020|
|Data ahead of print / Data di stampa:||27-dic-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu12010079|
|Appare nelle tipologie:||01 - Articolo su periodico|