Suppression of the immune system has been constantly reported in the last years as a classical side effect of opioid drugs. Most of the studies on the immunological properties of opioids refer to morphine. Although morphine remains the "reference molecule," other semisynthetic and synthetic opioids are frequently used in the clinical practice. The primary objective of this review is to analyze the available literature on the immunomodulating properties of opioid drugs different from morphine in preclinical models and in the human. A search strategy was conducted in PubMed, Embase, and the Cochrane databases using the terms "immunosuppression," "immune system," "opioids," "Natural killer cells," "cytokines," and "lymphocytes." The results achieved concerning the effects of fentanyl, methadone, oxycodone, buprenorphine, remifentanil, tramadol, and tapentadol on immune responses in animal studies, in healthy volunteers and in patients are reported. With some limitations due to the different methods used to measure immune system parameters, the large range of opioid doses and the relatively scarce number of participants in the available studies, we conclude that it is not correct to generalize immunosuppression as a common side effect of all opioid molecules.
Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies / S. Franchi, G. Moschetti, G. Amodeo, P. Sacerdote. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 10(2019 Dec 12).
|Titolo:||Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies|
MOSCHETTI, GIORGIA (Secondo)
AMODEO, GIADA (Penultimo)
SACERDOTE, PAOLA GIUSEPPINA (Ultimo) (Corresponding)
|Parole Chiave:||morphine; immunosuppression; fentanyl; buprenophine; oxycodone; methadone; tramadol; tapentadol|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Progetto:||Treating pain to modulate frailty: a bench to bedside mechanism based model|
|Data di pubblicazione:||12-dic-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fimmu.2019.02914|
|Appare nelle tipologie:||01 - Articolo su periodico|