IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishTrans-1-amino-3-18F-fluorocyclobutanecarboxylic-acid (anti-[18F]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of 18F-FACBC positron emission tomography/computed-tomography (PET/CT) in the detection of primary/recurrent PCa. A bibliographic search was performed including several databases, using the following terms: “FACBC”/“fluciclovine” AND “prostate cancer”/“prostate” AND “PET”/“Positron Emission Tomography”. Fifteen and 9 studies were included in the systematic reviews and meta-analysis, respectively. At patient-based analysis, the pooled sensitivity and specificity of 18F-FACBC-PET/CT for the assessment of PCa were 86.3% and 75.9%, respectively. The pooled diagnostic odds-ratio value was 16.453, with heterogeneity of 30%. At the regional-based-analysis, the pooled sensitivity of 18F-FACBC-PET/CT for the evaluation of primary/recurrent disease in the prostatic bed was higher than in the extra-prostatic regions (90.4% vs. 76.5%, respectively); conversely, the pooled specificity was higher for the evaluation of extra-prostatic region than the prostatic bed (89% vs. 45%, respectively). 18F-FACBC-PET/CT seems to be promising in recurrent PCa, particularly for the evaluation of the prostatic bed. Additional studies to evaluate its utility in clinical routine are mandatory.
18F-FACBC in prostate cancer : a systematic review and meta-analysis / R. Laudicella, D. Albano, P. Alongi, G. Argiroffi, M. Bauckneht, S. Baldari, F. Bertagna, M. Boero, G. De Vincentis, A. Del Sole, G. Rubini, L. Fantechi, V. Frantellizzi, G. Ganduscio, P. Guglielmo, A.G. Nappi, L. Evangelista. - In: CANCERS. - ISSN 2072-6694. - 11:9(2019 Sep), pp. 1348.1-1348.15.
| Titolo: | 18F-FACBC in prostate cancer : a systematic review and meta-analysis |
| Autori: | |
| Parole Chiave: | 18; F-FACBC; Meta-analysis; PET/CT; Prostate cancer; Recurrence; Review |
| Settore Scientifico Disciplinare: | Settore MED/36 - Diagnostica per Immagini e Radioterapia |
| Data di pubblicazione: | set-2019 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/cancers11091348 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Laudicella et al. - 2019 - 18F-Facbc in Prostate Cancer A Systematic Review and Meta-Analysis.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |
Copyright © 2021