Trans-1-amino-3-18F-fluorocyclobutanecarboxylic-acid (anti-[18F]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of 18F-FACBC positron emission tomography/computed-tomography (PET/CT) in the detection of primary/recurrent PCa. A bibliographic search was performed including several databases, using the following terms: “FACBC”/“fluciclovine” AND “prostate cancer”/“prostate” AND “PET”/“Positron Emission Tomography”. Fifteen and 9 studies were included in the systematic reviews and meta-analysis, respectively. At patient-based analysis, the pooled sensitivity and specificity of 18F-FACBC-PET/CT for the assessment of PCa were 86.3% and 75.9%, respectively. The pooled diagnostic odds-ratio value was 16.453, with heterogeneity of 30%. At the regional-based-analysis, the pooled sensitivity of 18F-FACBC-PET/CT for the evaluation of primary/recurrent disease in the prostatic bed was higher than in the extra-prostatic regions (90.4% vs. 76.5%, respectively); conversely, the pooled specificity was higher for the evaluation of extra-prostatic region than the prostatic bed (89% vs. 45%, respectively). 18F-FACBC-PET/CT seems to be promising in recurrent PCa, particularly for the evaluation of the prostatic bed. Additional studies to evaluate its utility in clinical routine are mandatory.
18F-FACBC in prostate cancer : a systematic review and meta-analysis / R. Laudicella, D. Albano, P. Alongi, G. Argiroffi, M. Bauckneht, S. Baldari, F. Bertagna, M. Boero, G. De Vincentis, A. Del Sole, G. Rubini, L. Fantechi, V. Frantellizzi, G. Ganduscio, P. Guglielmo, A.G. Nappi, L. Evangelista. - In: CANCERS. - ISSN 2072-6694. - 11:9(2019 Sep), pp. 1348.1-1348.15.
|Titolo:||18F-FACBC in prostate cancer : a systematic review and meta-analysis|
|Parole Chiave:||18; F-FACBC; Meta-analysis; PET/CT; Prostate cancer; Recurrence; Review|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||set-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cancers11091348|
|Appare nelle tipologie:||01 - Articolo su periodico|
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|Laudicella et al. - 2019 - 18F-Facbc in Prostate Cancer A Systematic Review and Meta-Analysis.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|