Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.
Vitamin K effects in human health: new insights beyond bone and cardiovascular health / M. Fusaro, M. Gallieni, C. Porta, T.L. Nickolas, P. Khairallah. - In: JN. JOURNAL OF NEPHROLOGY. - ISSN 1121-8428. - 33:2(2020 Apr), pp. 239-249. [10.1007/s40620-019-00685-0]
Vitamin K effects in human health: new insights beyond bone and cardiovascular health
M. GallieniSecondo
;
2020
Abstract
Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.File | Dimensione | Formato | |
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Fusaro et alSubmitted 28nov2019 VitK JN JNEP-D-19-00632_R1.pdf
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Fusaro2019_Article_VitaminKEffectsInHumanHealthNe.pdf
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