Background: Iron deficiency (ID) is a known co-morbidity and a potential therapeutic target in heart failure. Whether ID is frequent also in ST-segment elevation acute myocardial infarction (STEMI) patients and is associated with worse in-hospital outcomes has never been evaluated. Methods: We defined ID as a serum ferritin < 100 mu g/L or transferrin saturation < 20% at hospital admission. We assessed the association between ID and the primary endpoint (a composite of in-hospital mortality and Killip class >= 3). We explored the potential association between ID, circulating cell-free mitochondrial DNA (mtDNA), and cardiac magnetic resonance (CMR) parameters. Results: Four-hundred-twenty STEMI patients undergoing primary percutaneous coronary intervention (pPCI) were included. Of them, 237 (56%) had ID. They had significantly higher admission high-sensitivity troponin and mtDNA levels as compared to non-ID patients (145 +/- 35 vs. 231 +/- 66 ng/L, P < 0.001; 917 [404-1748] vs. 1368 [908-4260] copies/mu L; P < 0.003, respectively). A lower incidence of the primary endpoint (10% vs. 18%, P = 0.01) was observed in ID patients (adjusted OR 0.50 195% CI 0.27-0.931; P = 0.02). At CMR ( n = 192), ID patients had a similar infarct size (21 +/- 18 vs. 21 +/- 19 g; P = 0.95), but a higher myocardial salvage index (0.56 +/- 0.30 vs. 0.43 +/- 0.27; P = 0.002), and a smaller microvascular obstruction extent (3.6 +/- 2.2 vs. 6.9 +/- 3.9 g; P < 0.001). Conclusions: Iron deficiency is frequent in STEMI patients, it is coupled with mitochondrial injury, and, paradoxically, with a better in-hospital outcome. This unexpected clinical result seems to be associated with a smaller myocardial reperfusion injury. The mechanisms underlying our findings and their potential clinical implications warrant further investigation.

Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention / N. Cosentino, J. Campodonico, G. Pontone, M. Guglielmo, M. Trinei, M.T. Sandri, RIGGIO DANIELA, BAGGIANO ANDREA, MILAZZO VALENTINA, M. Moltrasio, G. Muscogiuri, A. Bonomi, S. Barbieri, E. Assanelli, G. Lauri, A. Bartorelli, G. Marenzi. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 300(2020 Feb 01), pp. 14-19. [10.1016/j.ijcard.2019.07.083]

Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

N. Cosentino
Primo
;
G. Pontone;D. Riggio;A. Baggiano;V. Milazzo;A. Bartorelli;
2020-02-01

Abstract

Background: Iron deficiency (ID) is a known co-morbidity and a potential therapeutic target in heart failure. Whether ID is frequent also in ST-segment elevation acute myocardial infarction (STEMI) patients and is associated with worse in-hospital outcomes has never been evaluated. Methods: We defined ID as a serum ferritin < 100 mu g/L or transferrin saturation < 20% at hospital admission. We assessed the association between ID and the primary endpoint (a composite of in-hospital mortality and Killip class >= 3). We explored the potential association between ID, circulating cell-free mitochondrial DNA (mtDNA), and cardiac magnetic resonance (CMR) parameters. Results: Four-hundred-twenty STEMI patients undergoing primary percutaneous coronary intervention (pPCI) were included. Of them, 237 (56%) had ID. They had significantly higher admission high-sensitivity troponin and mtDNA levels as compared to non-ID patients (145 +/- 35 vs. 231 +/- 66 ng/L, P < 0.001; 917 [404-1748] vs. 1368 [908-4260] copies/mu L; P < 0.003, respectively). A lower incidence of the primary endpoint (10% vs. 18%, P = 0.01) was observed in ID patients (adjusted OR 0.50 195% CI 0.27-0.931; P = 0.02). At CMR ( n = 192), ID patients had a similar infarct size (21 +/- 18 vs. 21 +/- 19 g; P = 0.95), but a higher myocardial salvage index (0.56 +/- 0.30 vs. 0.43 +/- 0.27; P = 0.002), and a smaller microvascular obstruction extent (3.6 +/- 2.2 vs. 6.9 +/- 3.9 g; P < 0.001). Conclusions: Iron deficiency is frequent in STEMI patients, it is coupled with mitochondrial injury, and, paradoxically, with a better in-hospital outcome. This unexpected clinical result seems to be associated with a smaller myocardial reperfusion injury. The mechanisms underlying our findings and their potential clinical implications warrant further investigation.
Iron deficiency; Myocardial reperfusion injury; Primary percutaneous coronary intervention; ST-elevation myocardial infarction
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
31-lug-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/702967
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