Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.
Mucins and Asthma : Are We Headed to the Revolutionary Road? / P. Santus, D. Radovanovic, D.A. Chiumello. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:11(2019 Nov 13), pp. 1955.1-1955.4.
Mucins and Asthma : Are We Headed to the Revolutionary Road?
P. SantusPrimo
;D. RadovanovicSecondo
;D.A. Chiumello
Ultimo
2019
Abstract
Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.
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